Barcelona joined Real Madrid, Atletico and Real Sociedad in the semi-finals, with the draw set to take place on Wednesday.
Croatian forward Ante Budimir scored twice to help Osasuna earn a shock 4-2 home win over leaders Barcelona.
Bundesliga leaders Bayern Munich powered past third-placed Eintracht Frankfurt 4-0 with an impressive display of high-pressing football on Sunday.
IMAGES from the football matches played across Europe on Sunday.
In his absence, the league champions have made a lacklustre start to the season, losing their opening game to Athletic Bilbao before taking just four points from fixtures against Real Betis and Osasuna.
The following is the draw for the Champions League last 16 which was held in Nyon on Monday:
Sevilla scrambled to the top of La Liga with a scrappy 1-0 win at home to Real Valladolid, on Sunday, moving one point clear of champions Barcelona at the summit.
Barca's fans held up a mosaic before the game reading "Infinite Iniesta". They later revealed a banner saying "Thanks for so much" in tribute to a player who came through the club's academy and spent 16 years pulling the strings in midfield, winning nine Liga titles, four Champions Leagues and six domestic Cups.
Images from Saturday's action in La Liga.
Real Madrid's Javier Hernandez struck twice as they came from behind to beat Celta Vigo 4-2 away and keep the pressure on Barcelona at the top of La Liga on Sunday.
Lionel Messi had two free-kick attempts while ex-Sevilla midfielder Ivan Rakitic narrowly missed the target from inside the area.
Real Madrid moved back to the top of La Liga as Vinicius Junior scored both goals in a 2-1 victory at Elche on Saturday.
The win took Barca to the top of the standings on 68 points although Real Madrid, on 65, will reclaim their lead due to their superior head-to-head record if they beat Real Mallorca at home on Wednesday.
Champions Real Madrid were beaten at home by promoted Cadiz, while Barcelona fell to their first defeat in La Liga under new coach Ronald Koeman as they lost to Getafe.
Barca play their final league La Liga game of the season at Alaves on Sunday before hosting Napoli on Aug. 8 in the second leg of their Champions League last-16 tie.
The club could also sell other players to in order to create a new contract for Messi, who is the top scorer in La Liga this season with 13 goals.
A Marco Asensio-inspired Real Madrid crushed Eibar 3-0 to close the gap on La Liga leaders Barcelona to five points on Sunday, with Karim Benzema starting on the bench.
Barcelona players had their families and toddlers join in their La Liga title celebrations at the Camp Nou in Barcelona on Sunday.
Barcelona coach Pep Guardiola and leading scorer Lionel Messi described their 2011 La Liga crown as the toughest of titles after securing top spot with a 1-1 draw at Levante on Wednesday.
Real Madrid clinched a record-extending 34th La Liga title with one game to spare by beating Villarreal 2-1 at home on Thursday thanks to two goals from their leading scorer Karim Benzema. Real have 86 points after 37 games, seven more than deposed champions Barcelona who were beaten 2-1 at home to Osasuna.
Records promise to tumble again in the 2012-13 La Liga season as world powerhouses Real Madrid and Barcelona resume their duel for supremacy, threatening to cast Spain's other 18 clubs even further adrift.
Barca finished the season second in the standings on 82 points, four behind champions Real Madrid who visit Leganes later on Sunday. Alaves are 16th on 39.
The defender later became the club's assistant coach before embarking on an eventful career as a head coach, managing Dutch sides Ajax Amsterdam, PSV Eindhoven and Feyenoord plus Premier League sides Southampton and Everton and La Liga's Valencia.
"Both in terms of what you save on the wage bill as well as the money you make, it would've been desirable. But this is something the coaching staff have to consent to and that's not my place.
Pedro scored twice as Barcelona made heavy weather of beating promoted Levante 2-1 to move five points clear at the top of La Liga on Sunday.
Barcelona great Xavi Hernandez has said it is his dream to coach his former side
Barcelona travel to newly-promoted Osasuna without their first choice front line.
Barcelona failed to capitalise on Real Madrid dropping points against Villarreal as the La Liga champions were held to a 1-1 draw at home to Atletico Madrid on Wednesday, while talisman Lionel Messi limped off with a groin injury.
Messi agreed no-fee Barca exit clause in case of Catalan independence
Luis Suarez picked up a hamstring strain in Tuesday's Champions League match at Bayern Munich.
The Catalans have kept five clean sheets in their last six games, which bodes well for their title run in.
Thierry Henry was on target as Barcelona cruised to a 4-0 home win over Racing Santander on Saturday to move five points clear at the top of La Liga.
Lionel Messi marked his record 506th appearance for Barcelona in La Liga by scoring a penalty but the Catalans could only draw
Barcelona midfielder Andres Iniesta has failed to recover from a calf strain and will miss Tuesday's Champions League Group F match at APOEL Nicosia.
The season kick backs into action with a local derby between Sevilla and Real Betis on June 11 and there will be fixtures for the following seven days, with Barca hosting Leganes on June 16
Sporting marked the final home game of coach Ruben Amorim's reign in stunning fashion as Viktor Gyokeres' hat-trick saw them come from behind to thrash Manchester City 4-1 and maintain their superb start to the Champions League on Tuesday.
It was Messi's 30th goal in 39 competitive games against Atletico
Barca face La Liga leaders Real Sociedad on Wednesday hoping to build on their slender 1-0 victory over Levante after suffering painful defeats by Cadiz and Juventus and making their worst start to a league season in 33 years.
Leaders Barcelona survived red cards for Gerard Pique and Rafael Marquez to complete a 2-1 victory over Getafe in La Liga on Saturday while Real Madrid kept pace with a 3-0 win at home to Espanyol.
Barcelona rubber-stamped a decade of domestic dominance by clinching the La Liga title on Sunday
